"Cyclosporin": mirayiridzo kushandiswa. "Cyclosporin A": nokurairirwa. Eye anosiya pamwe cyclosporine

Zvakasikwa, pane zvinhu vanokwanisa kudzivisa cellular uye humoral kutapata mumuviri mhuka kuitwa T-lymphocytes. Zvinokwanisika tobudirira kuita nhengo kuisirwa uye kubata zvirwere chokuita vasingadzoreki zvirwere. Mumwe cyclosporin yakadaro dzinongoitika yeimwe.

tsananguro

Panovhurwa pafuma chokuita kudzidza fungal utachiona Tolypocladium inflatum uye Cylindrocarpon lucidum. Synthesized pamusoro pakugadzira vanoshingaira yomuchipatara akadai cyclosporin A neC kuratidza immunological basa pamusoro masero lymphocytic ropa. Nyaya iyi yokutanga yakawanikwa 1972 nemasayendisiti kubva "Sandoz" yacho yezvirwere Swiss. Zvakaonekwa kuti makemikari maumbirwo cyclosporine riri kwazvakarerekera lipophilic cyclic endecapeptide pamwe segwapa zvakananga immunosuppressive chiito.

Kwakavakirwa zvinodhaka vane kuita zvokusarudza musi T-lymphocytes vasaziva cellular uye humoral kutapata. Cyclosporin ropa kuchititadzisa kugadzirwa lymphokines, izvo zvinoderedza lymphocyte basa, asi asina zvainoita nedanho hematopoiesis uye basa phagocytes, zvichiratidza kuti chiito zvokusarudza kuti mukomboni mumuviri.

chipimo chemushonga siyana

Zvinofanira kuva wakanamatira ivavo Mbuva pamwe mishonga ine cyclosporin, murayiridzo Chinyorwa. Pakati pezvimwe zvinhu, chinosanganisira ruzivo pamusoro kusunungurwa chimiro zvinodhaka. Kugadzirira yamarudzi ichi anogadzirwa muchimiro:

• zvinyoronyoro capsules ane chipimo chemushonga 25, 50 uye 100 milligrams;
• chidhakwa zvokuudzwa mhinduro ne 100 milligrams pamusoro cyclosporin chete ml mhinduro;
• mafuta zvokuudzwa mhinduro ne 100 milligrams pamusoro cyclosporin chete ml mhinduro;
• pfungwa nokuda kwezvifananidzo zvaAtemisi mhinduro aizomupa vaitarira ne 50 uye 650 milligrams ose cyclosporin pa milliliter;
• ziso anodonhedza pamwe micrograms 500 paminiti milliliter kuti cyclosporine.

Zvichienderana kushandiswa chipimo chemushonga fomu ichava yakasiyana nokuti munyika kutarisira kuti jekiseni, nokuti kukamura uchishandisa kushanda.

Zvinofungidzirwa kuti mwero Absorção de Água yezviri zvinoriumba, kuunganidza nguva chemhando wevasungwa iri muropa Kamudzira uye kuitwa munyika kugamuchira vanoonekwa nerokuti.

Drug "Tacrolimus": dzomuzana

Munguva mishonga pamusika pane nhamba zvinodhaka anogadzirwa chete mishonga chimiro, uye kupa substantially zvimwechetezvo. The achishingaira pazvokudya pavo cyclosporine. Mirayiridzo kushandiswa anoreva zvakafanana immunodepressorov kufunga uchitsanangura zvinodhaka kudzvinyirira zvirwere siyana.

Pakati mishonga encapsulated mune nyoro gelatin goko uye nemvura zvinogadzirisa ndiyo yepakutanga chinodhaka "Sandimmun Neoral" zvinoberekwa Swiss mishonga kambani "Novartis". The zvimwe zvinodhaka vaiona kuburitswa mumufananidzo vakasikwa wokutanga murwiyo ane pfuma cyclosporin. Analogues akadai zvinodhaka "Cyclosporin hexane", "Ekoral", "Tsiklopren" "Cyclosporin A", anobudiswa muchimiro capsules kana mhinduro zvemukati kana kugamuchira majekiseni.

chinangwa chavo chikuru - kuderedza kuramba ari transplantation pamusoro zvomukati kana mwongo. Kuvabata sezvo autoimmune zvirwere, sezvinoratidzwa vasiyana mushonga "Tacrolimus" mirayiridzo kushandiswa. Analogs zvakafanana maitiro, uye zvairatidza kuti kushandiswa.

The mashandiro chiito "Cyclosporin A" chinodhaka

At moyo zvose zvinoitwa immunosuppressive zvinodhaka nomugumisiro zvokusarudza pamusoro T-lymphocytes. No Kusara uye zvinodhaka "Cyclosporin A". Guide oudzame anofukidza huru zvigadziriswe pharmacodynamic migumisiro yezviri zvinoriumba, runokusunganidzai kuti Kanotokonya idzodzo mukati masero. Zvinoderedza kugadzirwa mainterleukin uye interferon kunoderedza kutaura receptors nokuda IL-2.

Medicament "Cyclosporin A" kunoderedza kugadzirwa antibodies kutaurirwa pachake masero ayo uye munyama, zvavakanga funga mutorwa uye kuparadza. Nyaya iyi kunoita kuti kuderedza immunological zvirwere uye kuderedza basa autoimmune zvirwere.

kunyatsoshanda Great "Cyclosporin A" iri aremekedzwe allograft. Chikonzero kuramba wakasimwa nyama uye nhengo ndiyo activation kuti masoja T masero kunotangira. Ivo nokushingaira vanotanga kuti kubudiswa pasi nezvaizoitwa transplantation maantigen uye kukanganisa batanidza masero, zvichitungamirira rufu rwavo.

Action immunodepressora kunotungamirira ichivharira vang T-masero uye chinovhiringidza T-lymphocytes kuchimuka zvirwere siyana. Somugumisiro, kubudirira zvinodhaka "Cyclosporin A" (User rinoratidza ichi) rinowanikwa chete pashure kudzvinyirira pakati nokuisazve maantigen. Nokuparadza ukama antigen antibody wakavarambidza necrosis kuti wakasimwa nhengo masero.

Sei kushandisa

Zvairatidza Dzokushandisa "Tacrolimus" mirayiridzo kushandiswa kwezvinodhaka yakakamurwa muzvikamu zviviri.

Chokutanga transplantation kana transplantation kuti anyatsoronga rinenge nenyere. A mushonga kushandiswa kudzivirira kurambwa nhego kana tishu podsazhennogo. Kazhinji, asi grafts vakashandisa ganda, mwoyo, mumwongo mapapu, chiropa, itsvo, rwatata. Zvichida kushandisa zvinodhaka kubvisa kuramba kana vamwe immunosuppressive nevamiririri. chikamu wechipiri autoimmune zvirwere zvikuru chimiro. Uyewo mumiriri ushandiswe nokuda yakaderera kunyatsoshanda vamwe zvinodhaka.

In chii zvirwere tinobata zvinodhaka "Tacrolimus"? dzokushandisa zvinoratidza kusanganisira murayiridzo allocates chakasimba siyana atopic dermatitis uye neurodermatitis, kuratidzirwa psoriasis, dzinonzi rheumatoid arthritis, uye kunokanganisa duku majoini vari zvomoto. Possible kushandiswa uveitis pakati uye neshure zvikamu ziso apo zvomoto choroid uye the retina, uye nephrotic chirwere uye kemikari-gormonoustoychivoy hunhu.

rubvumo mitemo

Drug kurapwa inokurudzirwa chete pasi wezvokurapa pokudzora muchipatara. Yemanyorero kushandisa womukati chikumbiro kana intravenous donhwe, kunyange zvazvo zvatinofarira anopiwa kugamuchira nomumukanwa mhinduro kana capsules.

Tableware, kushandiswa kugadzirira mhinduro intravenous jekiseni inofanira zvakagadzirwa negirazi, panzvimbo polyvinyl chloride kudzivisa maitiro mafuta anonzi Castor.

Nokuti dilution of Kuisa pfungwa pachinhu akashandisa vasiri 0,9 muzana mhinduro kubva yavaibvisa chloride kana 5 muzana shuga mhinduro. Dilution iri kuitwa pamwero kubva 1:20 1: 100, zvichienderana nechinangwa. Kusuma mushonga zvishoma nezvishoma kubvira maviri nhanhatu maawa.

Asati transplanting nhengo kana nyama akasuma kare cyclosporin mhinduro kuti anenge mana gumi maawa. Kudzivisa sema kuratidzwa mune zvakafanana yakatarwa antiallergic kurapwa nezvimwe immunosuppressants. Pashure pevhiki mbiri intravenous yaitonga zvinodhaka nokuda nomumukanwa kushanda. The daily dose chairayirwa nachiremba wako, akatorwa kaviri mumaawa gumi.

Capsules anwe rose pasina kuzarura hamvuropu, kushambidzwa pasi nemvura. The mushonga iri mvura pamberi kushandiswa rakasanganiswa kupinda kunwa mvura girazi beaker. The Chinyorwa rinotsanangura nemashoko akadzama sei kuti rongonyora kuti pasuru uye sei kuti dhayira chigadzikiso kudzidza sirinji regirazi bhodhoro, kuti zvakanaka kusarudza zvakarurama huwandu mishonga. Mushure nokunwa mhinduro mugaba akanga nemvura uye kunwa mvura, kuti hakuna kurasikirwa dose.

Concomitant unoshandiswa contraindicated zvinodhaka uye bhuratifuru muto, izvo zvinoderedza kubata mushonga, uyewo panguva kurapwa anorambidzwa kubaya chete mhenyu attenuated uye Sera kubva rubella, poriyo, gwirikwiti, mumps.

chipimo chemushonga

Kana wakasimwa akura kubvuma rinotanga zuva dose pamusoro 10-14 milligrams por kilogram kurema muviri. Pashure manomwe nemana mazuva kurapwa kunoonekwa wevasungwa kuti cyclosporine muropa. Zvinonzi kufurirwa mwero Absorção de Água uye kutendeuka mumuviri. chakarurama Izvi zvinokosha kuongorora kuitira kudzivirira divi migumisiro uye kudzivisa kunaka aiita zvimwe zvinodhaka. Zvadaro, nezuva dose zvinodhaka ipfupi kusvika 3,6 milligrams muzana kilogram kurema muviri, rakakamurwa rinoshandiswa maviri. Kuchirapa yeplasma zviri cyclosporin Saka zvichisiyana 110 kusvika 410 nanograms muzana milliliter.

Pashure transplantation itsvo kugamuchira medicament ari dose kuti asingasviki matatu mana milligrams muzana kilogram kurema muviri kunogona kukonzera kurambwa.

Mwongo transplantation zvinoda kushandisa mubatanidzwa cyclosporine uye methotrexate. Vanechitsama mazuva asati nokuisazve murwere chinotarisirwa daily nomutsinga inobva 2.5 5 milligrams muzana kilogram muviri uremu zvinhu.

Pashure yezwi pakurapa capsules kutanga zuva dose kuti 12,5 milligrams por kilogram kurema muviri, iyo yakatorwa sezvo kaviri. Kurapa kwakadaro kwazvo zvinodhaka kunotora mitatu kusvika mwedzi mitanhatu. Zvishoma nezvishoma kudiwa kuderedza uwandu husingakuvadzi kusvikira pakupera kurapwa nguva.

Kubvisa kusachengeteka kukuru ezvinhu achishandisa wokutanga nezuva dose zvinodhaka kubva 12,5 kusvika 15 milligrams muzana kilogram kurema muviri (kutora nzira mbiri). mazuva makumi mashanu vanopedza chipimo chemushonga rutapudzo mashanu muzana nokuda vhiki, uye pashure pemwedzi mishanu kutora zvinodhaka kumugumo. mamwe marapirwo "Cyclosporin" medicament vakatakurwa kana akadzokorora kuita. Mirayiridzo yokushandisa, mhinduro dzine ruzivo pamusoro kupona wakasimwa nhengo (mwoyo, chitaka). Maererano nenhamba, rimwe gore akatambanudza makumi masere muzana.

Mabatirwo autoimmune zvirwere zvinoda chaizvo kutaura kuti kusarudza mishonga kuti chirwere nerimwe.

By pakugamuchira "Cyclosporin" gadziriro kudzidziswa Chinyorwa anokurudzira mabatiro chakakomba uveitis. Tinofanira kutanga zuva dose pamusoro 5-10 milligrams por kilogram kurema muviri uye omerera pairi kuderedza kuzvimba uye normalization Zvinhu ushande. Yawapiwa matatu kusvika gumi mwedzi. In chakakomba maronda ose akabatana prednisolone ari dose pakati 200 600 micrograms muzana kilogram nokushivirira uremu.

In zvakakomba psoriasis dose nezuva iri 2.5 milligram chete kilogram kurema muviri, kugamuchirwa rinoitwa mu nzira mbiri. The chipimo chemushonga ichiwedzerwa 1 milligram chete kilogram kurema muviri, asi hapana zvinopfuura 5 milligrams por kilogram, mazuva kana pashure matatu pashure mharuro yokurapa, hapana kuvandudzika. Rubvumo kukanzura pashure kwemavhiki matanhatu kana kurapwa isashande.

Nephrotic chirwere kwomuzvarirwo renal basa nedzevakuru aibatwa vachishandisa chipimo chemushonga zvinodhaka kusvika 6 milligrams muzana kilogram muviri uremu Vana - kusvika 5 milligrams muzana kilogram kurema muviri. Kana renal basa iri vasingadzoreki, chipimo chemushonga - hapana milligrams anopfuura 2,5 chete kilogram kurema muviri.

Panguva kurapwa ane cyclosporin tigutsikane kuteverwa mumashure muropa plasma. For kuchirapa efficacy kunoda wevasungwa kwayo muropa mune mari 60-160 nanograms por milliliter.

Mumwedzi yokutanga mitatu kunge kudzora creatinine pamwero muropa serum, sezvo kuwedzera chinoratidza ichi vanogona chiratidzo kutanga kurambwa ane wakasimwa nhengo kana chirwere cheitsvo. Nokuti vanhu vane Itsvo dziri kushanda zvakanaka, ari kuongorora rinoitwa kamwe ose mazuva gumi, kana pane kutyorwa, indekisi creatinine kunoyerwa ose mazuva manomwe. Kana wevasungwa yacho chinoratidza kupfuura micromoles 200 paminiti fő nevakura uye anopfuura 140 micromoles por fő vana vakatakura abolition zvinodhaka.

Nokuda zvichibvira chepfu zvinokonzerwa zvinodhaka rinoitwa nguva nenguva richiona nezvezvabuda zviri bilirubin, urea, amylase, magnesium uye potassium ions muropa, chiropa makemikari akatsunga.

Dzinonzi rheumatoid arthritis chinhu zvikuru chimiro muvhiki nhanhatu dzokutanga kubatwa kugadzirira "Cyclosporin" pane imwe dose pamusoro 2,5 milligrams por kilogram kurema muviri, zvichiteverwa kurapwa pamwe nezuva dose haafaniri kupfuudza 4 milligrams por kilogram kurema muviri. Kana murombo tolerability pamusoro medicament zvinokwanisika kuderedza mari zvayo shoma inobudirira dose. Zvichida wemishonga "Ciclosporin" mushonga pamwe shoma corticosteroids kana nonsteroidal Anti-anogumbura zvinodhaka.

Kwazvo marudzi atopic dermatitis ari kubatwa zuva Kutarisirwa mushonga ari dose vana 2,5 milligrams por kilogram kurema muviri. Kana pasina kushanda pashure pemazuva gumi ushandiswe kunonyanyisa daily dose - 5 milligrams por kilogram kurema muviri. Kana paine kuvandudzika rehurumende, Zvinokurudzirwa zvishoma nezvishoma rutapudzo iri dose kurapwa.

Rakashandiswa cyclosporine ziso? ziso madonhwe

Immunosuppressive yomuchipatara dzave kushandiswa ophthalmology nokuda kurapwa yeziso rakaoma. Zvinangwa izvi, cyclosporine. Eye anosiya zvirimo (0.05 muzana) vari kutengeswa pasi tradename "Restasis".

mumiririri uyu ndohwaJehovha boka inoshandiswa kudzivirira cornea uye humidification. Yakabudiswa gadziriro iri chete dose pakati 0,4 milligram ndiro ari kugutsikana mune imwe milliliter pakati mhinduro 500 MG kuti basa chirungiso.

Chii Pharmaceuticals kunoratidza cyclosporine? Ziso Madonhwe kubereka Anti-anogumbura, immunomodulatory chaizvoizvo tunodzivisa kugadzirwa lachrymal secretion panguva yakaoma keratoconjunctivitis.

Sei kushandisa zvinodhaka "Restasis"

Munharaunda kushandiswa rinoreva "Restasis" chine cyclosporin. Usage Guide anokurudzira eyedrops kutanga zunzai chinu kuwana homogeneous opaque chena emulsion. Chete zvino unogona kutanga vatidzidzise madonhwe kupinda pakati conjunctival zai kuti murwere ziso. nzira iyi rinoitwa kaviri pazuva, ose maawa gumi. In kushandisa zvinodhaka haafaniri kubata pamucheto ziso mucosa chinu kudzivirira ingress chirwere mune mhinduro. Zvakakosha kurangarira kuti unofanira kushandisa mishonga pakarepo mushure kuvhura chinu, vakasarira mhinduro isina kushandiswa, zvinonzi kushandiswa.

No mushonga "Restasis" mushonga kana kupfeka kuonana lenses. Ivo vanobviswa asati kushandisa chemhinduro, uye zvinogona reinserted pashure maminitsi gumi nemashanu chete.

Kushandiswa cyclosporine mhuka

Parizvino, mumiririri uyu immunosuppressive rinoshandiswa nokuda pakurapa autoimmune nezvirwere imbwa uye dzimwe mhuka.

Pakutanga chete vanhu vachishandisa cyclosporine. "Sandimmune" - mafuta mhinduro ine aripo remubatanidzwa kana inoshandiswa varwere vakasiyana akakonzera yakasiyana Kuwanda basa pazvokudya plasma.

zvakawanda ano chimiro akasikwa ipapo - ultramicronized cyclosporine ( "Neoral"). Zvinoita kuti paumbwe imwe microemulsion panguva kudyidzana pamwe nemvura. Izvi zvakaita kuti kuvandudzika Absorção de Água uye bioavailability zvinodhaka zvakasiyana mafuta mhinduro dzisina akakodzera mhuka.

Musiki wemhuka chimiro zvinodhaka anoonekwa kambani "Novartis". Marezinesi mushonga yakabudiswa muna 2003 rinonzi "atopic", Mwari akaronga kuti kurapa atopic dermatitis kwemhuka. Kusvikira panguva iyoyo, kurongwa immunosuppressants kushandiswa nokuda nokuisazve itsvo katsi nembwa nokuda zvakazorodza zviratidzo anogumbura kwendangariro.

Zviratidzo atopic dermatitis kazhinji nokuonekwa imbwa duku nekatsi pakati pemakore kwemwedzi mitanhatu kusvikira makore matatu. Zviri chirwere dzinoratidzwa idzokororo zvazvo. It anofanira kubatwa gadziriro youpenyu hwose ane cyclosporine. Mirayiridzo kushandiswa mhuka "atopic" zvinoreva pfungwa zvichiita kurishandisa nguva zvinobudirira uye ngozi.

With mawa chikafu yaunodya nemishonga kuti kuchinja Absorção de Água, Zvinokurudzirwa kuti kutora mudziyo mumaawa maviri pashure kana pamberi kudya.

Pakati kupedzisira migumisiro kushandiswa kwezvinodhaka zvinowanza zvirwere munyika zvomudumbu ino, asi vari kuratidzwa nyore nenzira. Mhiri Marwadzo zviratidzo hypertrichosis, gingival hyperplasia isiri yekenza uye hyperplastic dermatitis. Akaroromesawo chipimo chemushonga zvinodhaka ndiko zvavo kunyangarika zvishoma nezvishoma.

Kugamuchira cyclosporin kunoderedza kukura staphylococcal noutachiona uye utachiona malassezioznogo dermatitis, mune mishonga dose haakonzeri itsvo kukundikana, BP, inotungamirwa neoplasms. All izvi anoratidza yakaderera mukana yematambudziko munguva kurapwa kwenguva refu kuti atopic dermatitis mune imbwa.