Ndeipi natriuretic peptides?

Sezvo akanga munyaya ichangobva kare, kuwedzera kune pachena mabasa mwoyo anoita basa kwemakemikari anobudiswa nenyere. It vafarire kwete chete pakati theorists zvokurapa, asi pakati vanoita. Natriuretic peptides (NUP) akacherekedza kwete myocardium, asiwo mune zvimwe zvomukati, kare vazvidzisa kwemakemikari anobudiswa mumuviri. Wakaitwa sarudzo seboka kushandisa quantitative zviratidzi NFA muropa kuti Kufembera cardiac pathologies, sezvo nzira iyi yaiva muduku invasive uye nyore kuti murwere.

Yawanikwa kwemakemikari anobudiswa kushanda mwoyo

Natriuretic peptides vave zvakawanikwa muna eighties remakore rapfuura, apo vasayendisiti ndaona kubatana pakati makakatanwa mwoyo makamuri uye kusimba ari secretion kuti weti. The Kuwanika Pakutanga akafunga kuti dzepanguva chakajairika uye akachipa zvichireva.

Gare gare, apo kudzidza mubvunzo uyu anobva pathologists uye histology, vakawana kuti masero ari zvinyama, chikamu atrium, pane inclusions ane mapuroteni mamorekuru pachavo. Zvave experimentally akaratidza kuti mushoma kubva atria makonzo pave yakasimba diuretic kushanda. Zvadaro vakabudirira nevamwe ari peptide uye kutevedzana kwezviitiko amino asidhi residues kuti kunobvumirwa nayo.

Papera nguva biochemists kuziva munhu puroteni ari matatu akaparadzana zvinoriumba (Alpha, Beta uye wegamma), zvakasiyana kwete nemakemikari yakarongeka, asi anewo nezvaizoitwa Arifa raiva nesimba kupfuura vamwe vaviri. Parizvino kusiyaniswa:

- atrial NUP (mhando A);
- chepfungwa NUP (mhando B);
- urodilatin (mhando C).

Nemakemikari omuviri natriuretic peptide

natriuretic peptides vose zvakafanana marongerwo uye akasiyana chete pakupedzisira nitrogenous radicals kana urongwa kabhoni maatomu. Nhasi, kuteerera zvose rinonyatsotarira mishonga NUP mhando B, sezvo ane yakatsiga zvikuru chimiro plasma, uye inokupai iwe kuti zvavataura zvawanikwa. Atrial NFA kuridza basa rimwe correctors nemvura electrolyte pakuenzanisa muviri. It anogadzirwa myocardium zvose zvinoitika uye chirwere chemwoyo.

Kunoratidzwa kuti aizotangira kwouropi NUP ine 108 amino asidhi residues vari synthesized ne masero ventricle kuruboshwe. Kana Morekuru otshnurovyvaetsya kubva cytoplasm, iyo enzayemu furin chiito pamusoro payo, izvo zvinoita mapuroteni urwu chacho vanoshingaira chimiro (32 amino acids of 108). NUP uropi ariko neropa maminitsi 40 chete, ipapo yaora. Kuwedzera puroteni usage chokuita rakawedzera ventricular rusvingo makakatanwa uye cardiac ischemia.

Excretion UNYP kubva yeplasma rinoitwa mu nzira huru mbiri:

- cleavage pamusoro lysosomal makemikari;
- proteolysis.

A aitungamirira basa iri akadzora kwakabatsira kwazvakarerekera endopeptidase Morekuru, asi zvose nzira dzinobatsira kuti kubviswa pakati natriuretic peptides.

Kanotokonya hurongwa

Migumisiro Vose natriuretic peptides anoteererwa nokuda kudyidzana pamwe receptors dzavo iri muuropi, tsinga, tsandanyama, mapfupa uye adipose tishu. Yakaenzana nezvemarudzi matatu NFA uye kune mhando nhatu receptors - A, B uye C. Zvisinei, kuparadzira "mabasa" kwete saka pachena:

- mhando A receptors anosangana atrial uye pfungwa NUP;
- The mhando ikasakendenga chete urodilatin;
- receptors anogona kusungira vose vatatu marudzi mamorekuru.

Receptors muri vangasimudzira vakasiyana mumwe. A uye B mhando akagadzirirwa kuti pave intracellular Migumisiro natriuretic peptide receptors uye mhando C zvinodiwa kuti biodegradation mapuroteni mamorekuru. Pane kufungidzira kuti nokufumura chepfungwa UNYP kuitwa kwete chete nokuda mhando A Kanotokonya, asiwo vamwe vachifunga zvikamu zviri vanoteerera chitsama cyclic guanosine monophosphate.

Nhamba chikuru mhando C receptors zvinowanikwa uropi, adrenal omumuviri, itsvo, nemidziyo. Apo UNYP Morekuru anosunga kuti Kanotokonya kuti mhando C, zviri yokuita zvinoitwa muchitokisi uye dzainamatira vakasununguka Kanotokonya iri vakadzokera membrane.

Physiology natriuretic peptide

Brain uye atrial natriuretic peptides vanoshandisa migumisiro zvavo kuburikidza ezvinhu akaoma vasiri mhinduro. Asi ivo vose pakupedzisira kutungamirira kuti chinangwa chete - achidzikisa preload pamwoyo. NUP rinokanganisa zvemwoyo, kwemakemikari anobudiswa, excretory uye nechepakati tsinga.

Sezvo mamorekuru izvi vane achida kuti receptors siyana, ari womumhuri, migumisiro mamwe NFA iri imwe gadziriro, zvakaoma. Zvakare, peptide kwepasi hakubvi chete zvayo mhando, asi nzvimbo vachifunga Kanotokonya.

Atrial natriuretic peptide rinoreva vasoactive peptides, i.e. zvakananga kubatsira vascular dhayamita. Asi kunze kuti anogona zvinowedzera kugadzirwa nitric oxide iyo kunosimudzirawo vasodilation. NUP A uye B zvakafanana mhando uye kutungamirirwa simba kuita marudzi ose midziyo, uye P-mhando zvikuru anowedzera chete mutsinga.

Recently zvave kuti NFA anofanira kunzwisisa chete sechinhu vasodilator, asi zvikurukuru somunhu antagonist kuti vasoconstrictor. Uyezve, pane zvidzidzo zvinoratidza kuti natriuretic peptides kupesvedzera kugovera Urume uye kubva rirambe richibvira Network.

Renal Migumisiro natriuretic peptide

Pamusoro natriuretic peptide zvingataurwa kuti chinhu rinodhaka diuresis. Zvikurukuru NUP mhando A kunowedzera renal ropa kuyerera uye anowedzera nevamwe nhumbi glomeruli. Izviwo, inowedzera glomerular filtration. Panguva iyoyowo NUP mhando C kunowedzera excretion pamusoro yavaibvisa ions, uye izvi zvinotungamirira kumwezve kurasikirwa mvura.

With zvose izvi nechimuko kuchikosha munyika kufurirwa haina kuchengetwa, kunyange kana peptide pamwero yakawedzera kakawanda. nyanzvi dzose dzinobvumirana kuti migumisiro kuti natriuretic peptides kushanda musi itsvo, zvinodiwa kuti kururamiswa nemvura electrolyte zvakanakanaka chisingaperi pathologies pakati kumwoyo.

Zvazvinoita pamusoro CNS

Brain natriuretic peptide sezvo atrial, haagoni zvinopfuura ropa-uropi nokuidzivirira. Saka, havana chokuita tsinga zvivako iri kunze kwayo. Asi apo vamwe NFA riri secreted ne uropi membranes dzaro dzimwe nzvimbo.

The nechepakati Migumisiro natriuretic peptides vavete chokwadi kuti kusimbisa huripo kuchinja peripheral. Saka, somuenzaniso, pamwe zvinoderedza cardiac preload muviri zvinoderedza kudiwa wayo mvura uye zvicherwa munyu, uye achichinjwawo mataurire autonomic tsinga nenzira iri parasympathetic chikamu.

rabhoritari zvezvinangwa

Pfungwa kutora natriuretic peptide Kuongororwa panguva kusagadzikana kumwoyo dzakatangira okutanga 90-ies wekupedzisira remakore. A gumi gare gare, mabhuku okutanga nemigumisiro pakutsvakurudza munharaunda iyi. Zvinonzi B-mhando NPU anodzidzisa pakuongorora kwokuomerwa mwoyo nokukundikana uye vachifanotaura kunoita chirwere.

Protein kugutsikana akanga akatsunga ropa venous rose, hwakakanyiwa EDTA, kana kushandisa immunochemical kuongorora. Kazhinji UNYP pamwero haafaniri kupfuudza 100 Ng / Rine mamiririta. Uyezve, zvinoita kuti kuziva padanho aizotangira NFA to electrochemiluminescent nzira. Domestic mushonga, kwete kuva rinoshandiswa zvakasiyana siyana zvakabatana immunosorbent munhu akaidza sezvo zvakasikwa nzira Pakusarudza huwandu rimwe fuma muropa serum yakadaro.

Kutsunga cardiac dysfunction

Natriuretic peptide (wokuyera - kusvika 100 kumar / Rine mamiririta) pari kupfuura akakurumbira uye chinonyanya ano zvechinguvana nokuda Pakusarudza cardiac tsandanyama dysfunction. The zvidzidzo zviri peptides okutanga kwakabatana matambudziko Kusiyanisa echirwere kweropa kukundikana uye chisingaperi obstructive pulmonary chirwere. Sezvo kurapwa zviratidzo zvakanga zvakafanana, muedzo kunobatsira kuziva chikonzero zvirwere uye akafembera pakuzadzisa chirwere.

The zvokurwara wechipiri, izvo ndavhiyiwa kudzidza kubva pamaonero ichi, chaiva chirwere mwoyo ischemic. Vanyori zvidzidzo vanobvuma kuti tsanangudzo NFA chechetere kunobatsira kusimbisa Zvinofungidzirwa kufa kana dzokororo mune murwere. Mukuwedzera, kukumikidza club NFA pamwero ndiyo chiratidzo kurapwa efficacy.

Pari pachiyero NFA atsunga mu varwere cardiomyopathy, BP, stenosis midziyo mikuru uye dzimwe kweropa zvirwere.

Shandisa mu cardiac kuvhiyiwa

Empirically chinoratidzwa kuti ufanane atrial natriuretic peptide muropa anogona sechinhu chokukomborerwa kwokuomerwa mamiriro uye nokushanda ventricle rworuboshwe Varwere vasati uye pashure cardiac kuvhiyiwa.

Kudzidza Fani iyi yakatanga muna 1993, asi chete asvika pamwero mukuru muna 2000s. It Vakawana kuti unopinza kuderera kwenhamba NUP ari peripheral ropa, kana pamberi ayo mwero kwave kwakaramba upgraded, kunoratidza kuti mashandiro ari myocardium ipfupi uye nokushanda akabudirira. Kana rutapudzo NFA hazvina kuitika, murwere akafa 100% mukana. The ukama pakati zera, pabonde uye pamwero mukuru peptide kunge kuzivikanwa, saka, nhamba iri pasi nokudenga vose Mapato wevarwere.

Fungidziro pashure pokuvhiyiwa

cardiac natriuretic peptide Vasati vavhiyiwa zvawanzwa. Pashure pezvose, kana dai zvisirizvo, ipapo kudiwa kurapwa akanga asipo. Yakakwirira pamwero NFA varwere vasati kurapwa zvisingafadzi. chinhu yakafurira zvikuru fungidziro pashure pakuvhiya.

Sezvo boka rakasarudzwa chidzidzo muduku, migumisiro vakanga yakavhenganiswa. Kudivi rimwe, kuziva zvakadini NFA vasati uye pashure kuvhiya rinobvumira vanachiremba kufungidzira izvo zvinodhaka uye mudziyo rubatsiro hunozodiwa kuti apedzise kuzoita pamwoyo mabasa ayo. Uyewo zvakanga akacherechedza kuti mari vakawedzera kubva NUP mhando B iri aizotangira kuti atrial fibrillation ari postoperative munguva.