Lozap Plus - Mirayiridzo Use

Medicine "Lozap ndinoiitawo" iri yaipiwa sezvo mahwendefa film-zvemapuranga, chiedza yeyero kana akacheneruka ruvara. Mahwendefa vane oblong chimiro uye kugovera ngozi rimwe divi.

mamiriro

Unorapa:

• hydrochlorothiazide - 12.5 MG; (1 Tab.)
• losartan - 50 MG (Table 1).

Excipients:

• macrogol 6000;
• microcrystalline cellulose;
• mannitol;
• krosparmelloza yavaibvisa;
• magnesium stearate;
• povidone;
• Valium;
• talc;
• dhayi;
• simethicone emulsion.

Pharmacological migumisiro

Losartan - ndiko angiotensin 2 Kanotokonya antagonist usingabereki tunodzivisa kinase 2. Kugadzirira kunoderedza OPSS, BP, ropa kwevari aldosterone uye epinephrine. Uyezve, mushonga une anobudirira diuretic kushanda uye kunoderedza afterload.

Losartan anogona kukudziridza zvokurwara akadai myocardial hypertrophy, uyewo kuvandudza kutsiga varwere tora mushonga uyu kuti mwoyo kukundikana.

Hydrochlorothiazide runobva kuna thiazide diuretics. It akazoita reabsorption kuti yavaibvisa uye anowedzera goho kuti potassium, phosphate uye rehydrogen iri weti.

Its kunonyanyisa antihypertensive mugumisiro ungasvika 3 mavhiki.

umboo

• neBP ari murwere;
• kuderedza ngozi CVD pavarwere vane yepamusoro kuruboshwe ventricular hypertrophy uye BP

nemishonga

Marwadzo ndinoiitawo Lozap inorondedzerwa mirayiridzo pachishandiswa kurutivi migumisiro yayo huru unorapa - losartan uye hydrochlorothiazide.

Side migumisiro chokuita nechepakati tsinga

• dzungu (kunoitika kakawanda zvakakwana).

Marwadzo kuti vanotsamwisa neutachiona muviri:

• angioedema;
• laryngeal edema (uye dzimwe nhengo yokumusoro kufema turakiti);
• mikoko;
• vasculitis;
• chirwere Enoki vake.

Side migumisiro chokuita zvemwoyo (kumwoyo):

• BP.

Side migumisiro chokuita zvomudumbu turakiti (mukana asingasviki 1%):

• chiropa;
• manyoka;
• kuwedzera chiropa transaminases.

Side migumisiro chokuita kufema hurongwa:

• kukosora.

Side migumisiro chokuita mvura-electrolyte mwero (mukana asingasviki 1%):

• hyperkalemia.

Contraindications

• neBP;
• anuria;
• hypovolemia;
• dysfunction kuti itsvo uye chiropa;
• makore 18;
• aikanganiswa zvakamisa hurongwa;
• pamuviri;
• lactation.

Kana murwere pamuviri kwakaitika pamusoro mamiriro zvinodhaka kuparadzwa, inofanira pakarepo kuti hazvichaiti. Chokwadi chokuti Lozap ndinoiitawo anokanganisa zvakananga renin-angiotensin hurongwa, izvo zvingaita kuti fetus rufu okupedzisira maviri trimesters akazvitakura.

Mahwendefa "Lozap ndinoiitawo" kutora murwere pamuviri achiri asina yakarumbidza nokuti mushonga kunogona kukonzera jaundice ari achangoberekwa, uye thrombocytopenia mu vanamai. Zvipatara vakaperekedza kushandisa diuretics, muchiitiko ichi hazvirevi kubatsira kudzivisa toxicity.

ovhadhozi

Zviratidzo ovhadhozi:

• BP;
• bradycardia;
• tachycardia;
• kupera mvura mumuviri (nokuda vawedzere weti goho).

ovhadhozi mushonga kurapwa kunofanira kutanga gastric lavage ari chiitiko kuti murwere atora Lozap ndinoiitawo achangobva. Ipapo murwere kunokosha symptomatic kurapwa, uye mune zvimwe zviitiko - kutsiurwa Urume uye electrolyte nenyonganiso. Hemodialysis havaizokwanisa kubvisa sezvo losartan uye ayo metabolites.

zvinodhaka kwavatori

Losap ndinoiitawo potentiates kuitwa zvimwe zvinodhaka antihypertensive panyaya kushandiswa kwavo yaisanganisa. The mushonga zvinogona kukonzera potentiation pamusoro orthostatic hypotension, panyaya kana aishanda pamwe barbiturates.